FOXP1-UBA3 Fusion FISH Probe
The FOXP1-UBA3 Fusion FISH Probe is used to confirm a fusion of the FOXP1 and UBA3 genes. The fusion of the FOXP1 and UBA3 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FOXP1-UBA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-RERE | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-REOR | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-REGO | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-REGR | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-REAQ | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-ORRE | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-OROR | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-ORGO | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-GORE | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-GOOR | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-GOGO | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-GOGR | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-GRRE | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-GROR | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-GRGO | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-GRGR | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-AQRE | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-AQOR | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-AQGO | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-AQGR | 20 (40 μL) | 200 μL |
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| FOXP1-UBA3-20-AQAQ | 20 (40 μL) | 200 μL |
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UBA3 Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Like Modifier Activating Enzyme 3
Chromosome: CHR3: 69103880 -69129524
Locus: 3p14.1
FOXP1 Gene Summary
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Forkhead Box P1
Chromosome: CHR3: 71004735 -71633140
Locus: 3p13
Gene Diseases
The FOXP1 UBA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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