FOXP1-FHIT Fusion FISH Probe
The FOXP1-FHIT Fusion FISH Probe is used to confirm a fusion of the FOXP1 and FHIT genes. The fusion of the FOXP1 and FHIT genes has been associated with Thymoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FOXP1-FHIT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-RERE | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-REOR | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-REGO | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-REGR | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-REAQ | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-ORRE | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-OROR | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-ORGO | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-ORAQ | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-GORE | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-GOOR | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-GOGO | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-GOGR | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-GOAQ | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-GRRE | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-GROR | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-GRGO | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-GRGR | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-GRAQ | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-AQRE | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-AQOR | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-AQGO | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-AQGR | 20 (40 μL) | 200 μL |
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| FOXP1-FHIT-20-AQAQ | 20 (40 μL) | 200 μL |
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FHIT Gene Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Name: Fragile Histidine Triad
Chromosome: CHR3: 59735035 -61237133
Locus: 3p14.2
FOXP1 Gene Summary
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Forkhead Box P1
Chromosome: CHR3: 71004735 -71633140
Locus: 3p13
Gene Diseases
The FOXP1 FHIT Fusion has been associated with the following diseases:
| Disease Name |
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| Thymoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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