FOXO1-MRPS31 Fusion FISH Probe
The FOXO1-MRPS31 Fusion FISH Probe is used to confirm a fusion of the FOXO1 and MRPS31 genes. The fusion of the FOXO1 and MRPS31 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FOXO1-MRPS31-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-RERE | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-REOR | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-REGO | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-REGR | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-REAQ | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-ORRE | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-OROR | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-ORGO | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-ORAQ | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-GORE | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-GOOR | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-GOGO | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-GOGR | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-GOAQ | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-GRRE | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-GROR | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-GRGO | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-GRGR | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-GRAQ | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-AQRE | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-AQOR | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-AQGO | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-AQGR | 20 (40 μL) | 200 μL |
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| FOXO1-MRPS31-20-AQAQ | 20 (40 μL) | 200 μL |
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FOXO1 Gene Summary
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Gene Name: Forkhead Box O1
Chromosome: CHR13: 41129800 -41240734
Locus: 13q14.11
MRPS31 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S31
Chromosome: CHR13: 41303431 -41345347
Locus: 13q14.11
Gene Diseases
The FOXO1 MRPS31 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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