FNIP2-RXFP1 Fusion FISH Probe
The FNIP2-RXFP1 Fusion FISH Probe is used to confirm a fusion of the FNIP2 and RXFP1 genes. The fusion of the FNIP2 and RXFP1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FNIP2-RXFP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-RERE | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-REOR | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-REGO | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-REGR | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-REAQ | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-ORRE | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-OROR | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-ORGO | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-GORE | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-GOOR | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-GOGO | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-GOGR | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-GRRE | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-GROR | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-GRGO | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-GRGR | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-AQRE | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-AQOR | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-AQGO | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-AQGR | 20 (40 μL) | 200 μL |
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| FNIP2-RXFP1-20-AQAQ | 20 (40 μL) | 200 μL |
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FNIP2 Gene Summary
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Gene Name: Folliculin Interacting Protein 2
Chromosome: CHR4: 159690181 -159827954
Locus: 4q32.1
RXFP1 Gene Summary
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Relaxin/insulin Like Family Peptide Receptor 1
Chromosome: CHR4: 159443046 -159573263
Locus: 4q32.1
Gene Diseases
The FNIP2 RXFP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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