FNIP2-LRAT Fusion FISH Probe
The FNIP2-LRAT Fusion FISH Probe is used to confirm a fusion of the FNIP2 and LRAT genes. The fusion of the FNIP2 and LRAT genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FNIP2-LRAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-RERE | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-REOR | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-REGO | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-REGR | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-REAQ | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-ORRE | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-OROR | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-ORGO | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-GORE | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-GOOR | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-GOGO | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-GOGR | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-GRRE | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-GROR | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-GRGO | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-GRGR | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-AQRE | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-AQOR | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-AQGO | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-AQGR | 20 (40 μL) | 200 μL |
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| FNIP2-LRAT-20-AQAQ | 20 (40 μL) | 200 μL |
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LRAT Gene Summary
The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Gene Name: Lecithin Retinol Acyltransferase
Chromosome: CHR4: 155665162 -155674270
Locus: 4q32.1
FNIP2 Gene Summary
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Gene Name: Folliculin Interacting Protein 2
Chromosome: CHR4: 159690181 -159827954
Locus: 4q32.1
Gene Diseases
The FNIP2 LRAT Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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