FNIP2-EXOC4 Fusion FISH Probe
The FNIP2-EXOC4 Fusion FISH Probe is used to confirm a fusion of the FNIP2 and EXOC4 genes. The fusion of the FNIP2 and EXOC4 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FNIP2-EXOC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-RERE | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-REOR | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-REGO | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-REGR | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-REAQ | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-ORRE | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-OROR | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-ORGO | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-GORE | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-GOOR | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-GOGO | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-GOGR | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-GRRE | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-GROR | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-GRGO | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-GRGR | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-AQRE | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-AQOR | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-AQGO | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-AQGR | 20 (40 μL) | 200 μL |
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| FNIP2-EXOC4-20-AQAQ | 20 (40 μL) | 200 μL |
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FNIP2 Gene Summary
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Gene Name: Folliculin Interacting Protein 2
Chromosome: CHR4: 159690181 -159827954
Locus: 4q32.1
EXOC4 Gene Summary
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Exocyst Complex Component 4
Chromosome: CHR7: 132937822 -133750513
Locus: 7q33
Gene Diseases
The FNIP2 EXOC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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