FNIP1-FBXO38 Fusion FISH Probe
The FNIP1-FBXO38 Fusion FISH Probe is used to confirm a fusion of the FNIP1 and FBXO38 genes. The fusion of the FNIP1 and FBXO38 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FNIP1-FBXO38-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-RERE | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-REOR | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-REGO | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-REGR | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-REAQ | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-ORRE | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-OROR | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-ORGO | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-ORAQ | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-GORE | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-GOOR | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-GOGO | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-GOGR | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-GOAQ | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-GRRE | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-GROR | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-GRGO | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-GRGR | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-GRAQ | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-AQRE | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-AQOR | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-AQGO | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-AQGR | 20 (40 μL) | 200 μL |
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| FNIP1-FBXO38-20-AQAQ | 20 (40 μL) | 200 μL |
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FBXO38 Gene Summary
This gene encodes a large protein that contains an F-box domain and may participate in protein ubiquitination. The encoded protein is a transcriptional co-activator of Krueppel-like factor 7 (Klf7). A heterozygous mutation in this gene was found in individuals with autosomal dominant distal hereditary motor neuronopathy type IID. There is a pseudogene for this gene on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Name: F-box Protein 38
Chromosome: CHR5: 147763545 -147822399
Locus: 5q32
FNIP1 Gene Summary
This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Gene Name: Folliculin Interacting Protein 1
Chromosome: CHR5: 130977406 -131132756
Locus: 5q31.1
Gene Diseases
The FNIP1 FBXO38 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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