FN1-UTRN Fusion FISH Probe
The FN1-UTRN Fusion FISH Probe is used to confirm a fusion of the FN1 and UTRN genes. The fusion of the FN1 and UTRN genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FN1-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| FN1-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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FN1 Gene Summary
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
Gene Name: Fibronectin 1
Chromosome: CHR2: 216225178 -216300791
Locus: 2q35
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The FN1 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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