FN1-EIF2AK2 Fusion FISH Probe
The FN1-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the FN1 and EIF2AK2 genes. The fusion of the FN1 and EIF2AK2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FN1-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| FN1-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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FN1 Gene Summary
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
Gene Name: Fibronectin 1
Chromosome: CHR2: 216225178 -216300791
Locus: 2q35
EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
Gene Diseases
The FN1 EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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