FN1-ATP2B4 Fusion FISH Probe
The FN1-ATP2B4 Fusion FISH Probe is used to confirm a fusion of the FN1 and ATP2B4 genes. The fusion of the FN1 and ATP2B4 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FN1-ATP2B4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-RERE | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-REOR | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-REGO | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-REGR | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-REAQ | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-ORRE | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-OROR | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-ORGO | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-ORAQ | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-GORE | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-GOOR | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-GOGO | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-GOGR | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-GOAQ | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-GRRE | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-GROR | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-GRGO | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-GRGR | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-GRAQ | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-AQRE | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-AQOR | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-AQGO | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-AQGR | 20 (40 μL) | 200 μL |
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| FN1-ATP2B4-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP2B4 Gene Summary
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: ATPase Plasma Membrane Ca2+ Transporting 4
Chromosome: CHR1: 203595914 -203713209
Locus: 1q32.1
FN1 Gene Summary
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
Gene Name: Fibronectin 1
Chromosome: CHR2: 216225178 -216300791
Locus: 2q35
Gene Diseases
The FN1 ATP2B4 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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