FLNB-SLMAP Fusion FISH Probe
The FLNB-SLMAP Fusion FISH Probe is used to confirm a fusion of the FLNB and SLMAP genes. The fusion of the FLNB and SLMAP genes has been associated with Bladder Urothelial Carcinoma, Breast Invasive Carcinoma, Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma, Pancreatic Adenocarcinoma, Esophageal Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FLNB-SLMAP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-RERE | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-REOR | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-REGO | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-REGR | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-REAQ | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-ORRE | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-OROR | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-ORGO | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-ORAQ | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-GORE | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-GOOR | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-GOGO | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-GOGR | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-GOAQ | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-GRRE | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-GROR | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-GRGO | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-GRGR | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-GRAQ | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-AQRE | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-AQOR | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-AQGO | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-AQGR | 20 (40 μL) | 200 μL |
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| FLNB-SLMAP-20-AQAQ | 20 (40 μL) | 200 μL |
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FLNB Gene Summary
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Gene Name: Filamin B
Chromosome: CHR3: 57994126 -58157982
Locus: 3p14.3
SLMAP Gene Summary
This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Gene Name: Sarcolemma Associated Protein
Chromosome: CHR3: 57743173 -57914894
Locus: 3p14.3
Gene Diseases
The FLNB SLMAP Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
| Breast Invasive Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
| Pancreatic Adenocarcinoma |
| Esophageal Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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