FLNA-ATP5G3 Fusion FISH Probe
The FLNA-ATP5G3 Fusion FISH Probe is used to confirm a fusion of the FLNA and ATP5G3 genes. The fusion of the FLNA and ATP5G3 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FLNA-ATP5G3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-RERE | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-REOR | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-REGO | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-REGR | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-REAQ | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-ORRE | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-OROR | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-ORGO | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-GORE | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-GOOR | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-GOGO | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-GOGR | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-GRRE | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-GROR | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-GRGO | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-GRGR | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-AQRE | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-AQOR | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-AQGO | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-AQGR | 20 (40 μL) | 200 μL |
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| FLNA-ATP5G3-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP5G3 Gene Summary
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified. [provided by RefSeq, Jun 2010]
Gene Name: ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit C3 (subunit 9)
Chromosome: CHR2: 176040985 -176046490
Locus: 2q31.1
FLNA Gene Summary
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Gene Name: Filamin A
Chromosome: CHRX: 153576899 -153603006
Locus: Xq28
Gene Diseases
The FLNA ATP5G3 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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