FKBP5-SRPK1 Fusion FISH Probe
The FKBP5-SRPK1 Fusion FISH Probe is used to confirm a fusion of the FKBP5 and SRPK1 genes. The fusion of the FKBP5 and SRPK1 genes has been associated with Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FKBP5-SRPK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-RERE | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-REOR | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-REGO | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-REGR | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-REAQ | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-ORRE | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-OROR | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-ORGO | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-GORE | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-GOOR | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-GOGO | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-GOGR | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-GRRE | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-GROR | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-GRGO | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-GRGR | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-AQRE | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-AQOR | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-AQGO | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-AQGR | 20 (40 μL) | 200 μL |
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| FKBP5-SRPK1-20-AQAQ | 20 (40 μL) | 200 μL |
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FKBP5 Gene Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Gene Name: FK506 Binding Protein 5
Chromosome: CHR6: 35541361 -35696360
Locus: 6p21.31
SRPK1 Gene Summary
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]
Gene Name: SRSF Protein Kinase 1
Chromosome: CHR6: 35800810 -35888957
Locus: 6p21.31
Gene Diseases
The FKBP5 SRPK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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