FKBP5-BYSL Fusion FISH Probe
The FKBP5-BYSL Fusion FISH Probe is used to confirm a fusion of the FKBP5 and BYSL genes. The fusion of the FKBP5 and BYSL genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FKBP5-BYSL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-RERE | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-REOR | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-REGO | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-REGR | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-OROR | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-GORE | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-GROR | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| FKBP5-BYSL-20-AQAQ | 20 (40 μL) | 200 μL |
|
BYSL Gene Summary
Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008]
Gene Name: Bystin Like
Chromosome: CHR6: 41888964 -41900784
Locus: 6p21.1
FKBP5 Gene Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Gene Name: FK506 Binding Protein 5
Chromosome: CHR6: 35541361 -35696360
Locus: 6p21.31
Gene Diseases
The FKBP5 BYSL Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|