FKBP1A-CDS2 Fusion FISH Probe
The FKBP1A-CDS2 Fusion FISH Probe is used to confirm a fusion of the FKBP1A and CDS2 genes. The fusion of the FKBP1A and CDS2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FKBP1A-CDS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-RERE | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-REOR | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-REGO | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-REGR | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-REAQ | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-ORRE | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-OROR | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-ORGO | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-GORE | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-GOOR | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-GOGO | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-GOGR | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-GRRE | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-GROR | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-GRGO | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-GRGR | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-AQRE | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-AQOR | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-AQGO | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-AQGR | 20 (40 μL) | 200 μL |
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| FKBP1A-CDS2-20-AQAQ | 20 (40 μL) | 200 μL |
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FKBP1A Gene Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
Gene Name: FK506 Binding Protein 1A
Chromosome: CHR20: 1349620 -1373816
Locus: 20p13
CDS2 Gene Summary
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]
Gene Name: CDP-diacylglycerol Synthase 2
Chromosome: CHR20: 5107406 -5178533
Locus: 20p12.3
Gene Diseases
The FKBP1A CDS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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