FKBP11-PRKAG1 Fusion FISH Probe
The FKBP11-PRKAG1 Fusion FISH Probe is used to confirm a fusion of the FKBP11 and PRKAG1 genes. The fusion of the FKBP11 and PRKAG1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FKBP11-PRKAG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-RERE | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-REOR | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-REGO | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-REGR | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-REAQ | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-ORRE | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-OROR | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-ORGO | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-GORE | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-GOOR | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-GOGO | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-GOGR | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-GRRE | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-GROR | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-GRGO | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-GRGR | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-AQRE | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-AQOR | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-AQGO | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-AQGR | 20 (40 μL) | 200 μL |
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| FKBP11-PRKAG1-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKAG1 Gene Summary
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase AMP-activated Non-catalytic Subunit Gamma 1
Chromosome: CHR12: 49396054 -49412629
Locus: 12q13.12
FKBP11 Gene Summary
FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]
Gene Name: FK506 Binding Protein 11
Chromosome: CHR12: 49315741 -49319330
Locus: 12q13.12
Gene Diseases
The FKBP11 PRKAG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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