FIP1L1-SORCS1 Fusion FISH Probe
The FIP1L1-SORCS1 Fusion FISH Probe is used to confirm a fusion of the FIP1L1 and SORCS1 genes. The fusion of the FIP1L1 and SORCS1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FIP1L1-SORCS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-RERE | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-REOR | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-REGO | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-REGR | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-REAQ | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-ORRE | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-OROR | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-ORGO | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-GORE | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-GOOR | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-GOGO | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-GOGR | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-GRRE | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-GROR | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-GRGO | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-GRGR | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-AQRE | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-AQOR | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-AQGO | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-AQGR | 20 (40 μL) | 200 μL |
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| FIP1L1-SORCS1-20-AQAQ | 20 (40 μL) | 200 μL |
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FIP1L1 Gene Summary
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Name: Factor Interacting With PAPOLA And CPSF1
Chromosome: CHR4: 54243819 -54326103
Locus: 4q12
SORCS1 Gene Summary
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Sortilin Related VPS10 Domain Containing Receptor 1
Chromosome: CHR10: 108333420 -108924466
Locus: 10q25.1
Gene Diseases
The FIP1L1 SORCS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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