FIP1L1-SBNO2 Fusion FISH Probe
The FIP1L1-SBNO2 Fusion FISH Probe is used to confirm a fusion of the FIP1L1 and SBNO2 genes. The fusion of the FIP1L1 and SBNO2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FIP1L1-SBNO2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-RERE | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-REOR | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-REGO | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-REGR | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-REAQ | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-ORRE | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-OROR | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-ORGO | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-ORAQ | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-GORE | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-GOOR | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-GOGO | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-GOGR | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-GOAQ | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-GRRE | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-GROR | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-GRGO | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-GRGR | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-GRAQ | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-AQRE | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-AQOR | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-AQGO | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-AQGR | 20 (40 μL) | 200 μL |
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| FIP1L1-SBNO2-20-AQAQ | 20 (40 μL) | 200 μL |
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SBNO2 Gene Summary
The Strawberry Notch Homolog 2 (SBNO2) gene is located on chr19 :1107632-1174282 at 19p13.3.
Gene Name: Strawberry Notch Homolog 2
Chromosome: CHR19: 1107632 -1174282
Locus: 19p13.3
FIP1L1 Gene Summary
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Name: Factor Interacting With PAPOLA And CPSF1
Chromosome: CHR4: 54243819 -54326103
Locus: 4q12
Gene Diseases
The FIP1L1 SBNO2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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