FILIP1-KCNQ5 Fusion FISH Probe
The FILIP1-KCNQ5 Fusion FISH Probe is used to confirm a fusion of the FILIP1 and KCNQ5 genes. The fusion of the FILIP1 and KCNQ5 genes has been associated with Uveal Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FILIP1-KCNQ5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-RERE | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-REOR | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-REGO | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-REGR | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-REAQ | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-ORRE | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-OROR | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-ORGO | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-ORAQ | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-GORE | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-GOOR | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-GOGO | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-GOGR | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-GOAQ | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-GRRE | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-GROR | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-GRGO | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-GRGR | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-GRAQ | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-AQRE | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-AQOR | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-AQGO | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-AQGR | 20 (40 μL) | 200 μL |
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| FILIP1-KCNQ5-20-AQAQ | 20 (40 μL) | 200 μL |
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FILIP1 Gene Summary
This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016]
Gene Name: Filamin A Interacting Protein 1
Chromosome: CHR6: 76017799 -76203496
Locus: 6q14.1
KCNQ5 Gene Summary
This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Name: Potassium Voltage-gated Channel Subfamily Q Member 5
Chromosome: CHR6: 73331570 -73908573
Locus: 6q13
Gene Diseases
The FILIP1 KCNQ5 Fusion has been associated with the following diseases:
| Disease Name |
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| Uveal Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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