FIG4-WASF1 Fusion FISH Probe
The FIG4-WASF1 Fusion FISH Probe is used to confirm a fusion of the FIG4 and WASF1 genes. The fusion of the FIG4 and WASF1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FIG4-WASF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-RERE | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-REOR | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-REGO | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-REGR | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-REAQ | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-ORRE | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-OROR | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-ORGO | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-GORE | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-GOOR | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-GOGO | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-GOGR | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-GRRE | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-GROR | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-GRGO | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-GRGR | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-AQRE | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-AQOR | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-AQGO | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-AQGR | 20 (40 μL) | 200 μL |
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| FIG4-WASF1-20-AQAQ | 20 (40 μL) | 200 μL |
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WASF1 Gene Summary
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: WAS Protein Family Member 1
Chromosome: CHR6: 110421021 -110501207
Locus: 6q21
FIG4 Gene Summary
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]
Gene Name: FIG4 Phosphoinositide 5-phosphatase
Chromosome: CHR6: 110012423 -110146634
Locus: 6q21
Gene Diseases
The FIG4 WASF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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