FIG4-PPP1R14C Fusion FISH Probe
The FIG4-PPP1R14C Fusion FISH Probe is used to confirm a fusion of the FIG4 and PPP1R14C genes. The fusion of the FIG4 and PPP1R14C genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FIG4-PPP1R14C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-RERE | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-REOR | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-REGO | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-REGR | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-REAQ | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-ORRE | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-OROR | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-ORGO | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-ORAQ | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-GORE | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-GOOR | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-GOGO | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-GOGR | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-GOAQ | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-GRRE | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-GROR | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-GRGO | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-GRGR | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-GRAQ | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-AQRE | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-AQOR | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-AQGO | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-AQGR | 20 (40 μL) | 200 μL |
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| FIG4-PPP1R14C-20-AQAQ | 20 (40 μL) | 200 μL |
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FIG4 Gene Summary
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]
Gene Name: FIG4 Phosphoinositide 5-phosphatase
Chromosome: CHR6: 110012423 -110146634
Locus: 6q21
PPP1R14C Gene Summary
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]
Gene Name: Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C
Chromosome: CHR6: 150464187 -150571528
Locus: 6q25.1
Gene Diseases
The FIG4 PPP1R14C Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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