FHOD3-MOCOS Fusion FISH Probe
The FHOD3-MOCOS Fusion FISH Probe is used to confirm a fusion of the FHOD3 and MOCOS genes. The fusion of the FHOD3 and MOCOS genes has been associated with Head And Neck Squamous Cell Carcinoma , Head And Neck Squamous Cell Carcinoma , and Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FHOD3-MOCOS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-RERE | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-REOR | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-REGO | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-REGR | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-OROR | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-GORE | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-GROR | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| FHOD3-MOCOS-20-AQAQ | 20 (40 μL) | 200 μL |
|
MOCOS Gene Summary
This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine. [provided by RefSeq, Apr 2017]
Gene Name: Molybdenum Cofactor Sulfurase
Chromosome: CHR18: 33767479 -33848685
Locus: 18q12.2
FHOD3 Gene Summary
The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015]
Gene Name: Formin Homology 2 Domain Containing 3
Chromosome: CHR18: 33877701 -34360018
Locus: 18q12.2
Gene Diseases
The FHOD3 MOCOS Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Head And Neck Squamous Cell Carcinoma |
| Head And Neck Squamous Cell Carcinoma |
| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|