SEARCH OUR PRODUCT CATALOG

FHOD3-ESRRB Fusion FISH Probe

The FHOD3-ESRRB Fusion FISH Probe is used to confirm a fusion of the FHOD3 and ESRRB genes. The fusion of the FHOD3 and ESRRB genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
FHOD3-ESRRB-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
FHOD3-ESRRB-20-RERE 20 (40 μL) 200 μL
FHOD3-ESRRB-20-REOR 20 (40 μL) 200 μL
FHOD3-ESRRB-20-REGO 20 (40 μL) 200 μL
FHOD3-ESRRB-20-REGR 20 (40 μL) 200 μL
FHOD3-ESRRB-20-REAQ 20 (40 μL) 200 μL
FHOD3-ESRRB-20-ORRE 20 (40 μL) 200 μL
FHOD3-ESRRB-20-OROR 20 (40 μL) 200 μL
FHOD3-ESRRB-20-ORGO 20 (40 μL) 200 μL
FHOD3-ESRRB-20-ORAQ 20 (40 μL) 200 μL
FHOD3-ESRRB-20-GORE 20 (40 μL) 200 μL
FHOD3-ESRRB-20-GOOR 20 (40 μL) 200 μL
FHOD3-ESRRB-20-GOGO 20 (40 μL) 200 μL
FHOD3-ESRRB-20-GOGR 20 (40 μL) 200 μL
FHOD3-ESRRB-20-GOAQ 20 (40 μL) 200 μL
FHOD3-ESRRB-20-GRRE 20 (40 μL) 200 μL
FHOD3-ESRRB-20-GROR 20 (40 μL) 200 μL
FHOD3-ESRRB-20-GRGO 20 (40 μL) 200 μL
FHOD3-ESRRB-20-GRGR 20 (40 μL) 200 μL
FHOD3-ESRRB-20-GRAQ 20 (40 μL) 200 μL
FHOD3-ESRRB-20-AQRE 20 (40 μL) 200 μL
FHOD3-ESRRB-20-AQOR 20 (40 μL) 200 μL
FHOD3-ESRRB-20-AQGO 20 (40 μL) 200 μL
FHOD3-ESRRB-20-AQGR 20 (40 μL) 200 μL
FHOD3-ESRRB-20-AQAQ 20 (40 μL) 200 μL

ESRRB Gene Summary

This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]

Gene Name: Estrogen Related Receptor Beta

Chromosome: CHR14: 76837689 -76968180

Locus: 14q24.3

FHOD3 Gene Summary

The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015]

Gene Name: Formin Homology 2 Domain Containing 3

Chromosome: CHR18: 33877701 -34360018

Locus: 18q12.2

Gene Diseases

The FHOD3 ESRRB Fusion has been associated with the following diseases:

Disease Name
Adrenocortical Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.