FHOD3-ELP2 Fusion FISH Probe
The FHOD3-ELP2 Fusion FISH Probe is used to confirm a fusion of the FHOD3 and ELP2 genes. The fusion of the FHOD3 and ELP2 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FHOD3-ELP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-RERE | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-REOR | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-REGO | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-REGR | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-REAQ | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-ORRE | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-OROR | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-ORGO | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-GORE | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-GOOR | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-GOGO | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-GOGR | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-GRRE | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-GROR | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-GRGO | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-GRGR | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-AQRE | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-AQOR | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-AQGO | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-AQGR | 20 (40 μL) | 200 μL |
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| FHOD3-ELP2-20-AQAQ | 20 (40 μL) | 200 μL |
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ELP2 Gene Summary
The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016]
Gene Name: Elongator Acetyltransferase Complex Subunit 2
Chromosome: CHR18: 33709836 -33754688
Locus: 18q12.2
FHOD3 Gene Summary
The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015]
Gene Name: Formin Homology 2 Domain Containing 3
Chromosome: CHR18: 33877701 -34360018
Locus: 18q12.2
Gene Diseases
The FHOD3 ELP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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