FHIT-STT3B Fusion FISH Probe
The FHIT-STT3B Fusion FISH Probe is used to confirm a fusion of the FHIT and STT3B genes. The fusion of the FHIT and STT3B genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FHIT-STT3B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-RERE | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-REOR | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-REGO | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-REGR | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-REAQ | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-ORRE | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-OROR | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-ORGO | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-ORAQ | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-GORE | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-GOOR | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-GOGO | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-GOGR | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-GOAQ | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-GRRE | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-GROR | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-GRGO | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-GRGR | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-GRAQ | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-AQRE | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-AQOR | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-AQGO | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-AQGR | 20 (40 μL) | 200 μL |
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| FHIT-STT3B-20-AQAQ | 20 (40 μL) | 200 μL |
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FHIT Gene Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Name: Fragile Histidine Triad
Chromosome: CHR3: 59735035 -61237133
Locus: 3p14.2
STT3B Gene Summary
The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]
Gene Name: STT3B, Catalytic Subunit Of The Oligosaccharyltransferase Complex
Chromosome: CHR3: 31574490 -31677556
Locus: 3p23
Gene Diseases
The FHIT STT3B Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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