FHIT-KHDRBS3 Fusion FISH Probe
The FHIT-KHDRBS3 Fusion FISH Probe is used to confirm a fusion of the FHIT and KHDRBS3 genes. The fusion of the FHIT and KHDRBS3 genes has been associated with Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FHIT-KHDRBS3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-RERE | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-REOR | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-REGO | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-REGR | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-REAQ | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-ORRE | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-OROR | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-ORGO | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-GORE | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-GOOR | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-GOGO | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-GOGR | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-GRRE | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-GROR | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-GRGO | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-GRGR | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-AQRE | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-AQOR | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-AQGO | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-AQGR | 20 (40 μL) | 200 μL |
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| FHIT-KHDRBS3-20-AQAQ | 20 (40 μL) | 200 μL |
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FHIT Gene Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Name: Fragile Histidine Triad
Chromosome: CHR3: 59735035 -61237133
Locus: 3p14.2
KHDRBS3 Gene Summary
The KH RNA Binding Domain Containing, Signal Transduction Associated 3 (KHDRBS3) gene is located on chr8 :136469715-136659848 at 8q24.23.
Gene Name: KH RNA Binding Domain Containing, Signal Transduction Associated 3
Chromosome: CHR8: 136469715 -136659848
Locus: 8q24.23
Gene Diseases
The FHIT KHDRBS3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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