FHIT-FAM19A4 Fusion FISH Probe
The FHIT-FAM19A4 Fusion FISH Probe is used to confirm a fusion of the FHIT and FAM19A4 genes. The fusion of the FHIT and FAM19A4 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FHIT-FAM19A4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-RERE | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-REOR | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-REGO | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-REGR | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-REAQ | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-ORRE | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-OROR | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-ORGO | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-ORAQ | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-GORE | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-GOOR | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-GOGO | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-GOGR | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-GOAQ | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-GRRE | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-GROR | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-GRGO | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-GRGR | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-GRAQ | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-AQRE | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-AQOR | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-AQGO | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-AQGR | 20 (40 μL) | 200 μL |
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| FHIT-FAM19A4-20-AQAQ | 20 (40 μL) | 200 μL |
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FHIT Gene Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Name: Fragile Histidine Triad
Chromosome: CHR3: 59735035 -61237133
Locus: 3p14.2
FAM19A4 Gene Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like
Chromosome: CHR3: 68780916 -68981711
Locus: 3p14.1
Gene Diseases
The FHIT FAM19A4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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