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FHIT-FAM19A4 Fusion FISH Probe

The FHIT-FAM19A4 Fusion FISH Probe is used to confirm a fusion of the FHIT and FAM19A4 genes. The fusion of the FHIT and FAM19A4 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
FHIT-FAM19A4-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
FHIT-FAM19A4-20-RERE 20 (40 μL) 200 μL
FHIT-FAM19A4-20-REOR 20 (40 μL) 200 μL
FHIT-FAM19A4-20-REGO 20 (40 μL) 200 μL
FHIT-FAM19A4-20-REGR 20 (40 μL) 200 μL
FHIT-FAM19A4-20-REAQ 20 (40 μL) 200 μL
FHIT-FAM19A4-20-ORRE 20 (40 μL) 200 μL
FHIT-FAM19A4-20-OROR 20 (40 μL) 200 μL
FHIT-FAM19A4-20-ORGO 20 (40 μL) 200 μL
FHIT-FAM19A4-20-ORAQ 20 (40 μL) 200 μL
FHIT-FAM19A4-20-GORE 20 (40 μL) 200 μL
FHIT-FAM19A4-20-GOOR 20 (40 μL) 200 μL
FHIT-FAM19A4-20-GOGO 20 (40 μL) 200 μL
FHIT-FAM19A4-20-GOGR 20 (40 μL) 200 μL
FHIT-FAM19A4-20-GOAQ 20 (40 μL) 200 μL
FHIT-FAM19A4-20-GRRE 20 (40 μL) 200 μL
FHIT-FAM19A4-20-GROR 20 (40 μL) 200 μL
FHIT-FAM19A4-20-GRGO 20 (40 μL) 200 μL
FHIT-FAM19A4-20-GRGR 20 (40 μL) 200 μL
FHIT-FAM19A4-20-GRAQ 20 (40 μL) 200 μL
FHIT-FAM19A4-20-AQRE 20 (40 μL) 200 μL
FHIT-FAM19A4-20-AQOR 20 (40 μL) 200 μL
FHIT-FAM19A4-20-AQGO 20 (40 μL) 200 μL
FHIT-FAM19A4-20-AQGR 20 (40 μL) 200 μL
FHIT-FAM19A4-20-AQAQ 20 (40 μL) 200 μL

FHIT Gene Summary

The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]

Gene Name: Fragile Histidine Triad

Chromosome: CHR3: 59735035 -61237133

Locus: 3p14.2

FAM19A4 Gene Summary

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]

Gene Name: Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like

Chromosome: CHR3: 68780916 -68981711

Locus: 3p14.1

Gene Diseases

The FHIT FAM19A4 Fusion has been associated with the following diseases:

Disease Name
Lung Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.