FGG-CLCN3 Fusion FISH Probe
The FGG-CLCN3 Fusion FISH Probe is used to confirm a fusion of the FGG and CLCN3 genes. The fusion of the FGG and CLCN3 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGG-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| FGG-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
FGG Gene Summary
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Gene Name: Fibrinogen Gamma Chain
Chromosome: CHR4: 155525285 -155533902
Locus: 4q32.1
Gene Diseases
The FGG CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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