FGFR3-TACC3 Fusion FISH Probe
The FGFR3-TACC3 Fusion FISH Probe is used to confirm a fusion of the FGFR3 and TACC3 genes. The fusion of the FGFR3 and TACC3 genes has been associated with Glioblastoma Multiforme, Glioblastoma Multiforme, Glioblastoma Multiforme, Glioblastoma Multiforme, Lung Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma, Kidney Renal Papillary Cell Carcinoma, Bladder Urothelial Carcinoma, Bladder Urothelial Carcinoma, Bladder Urothelial Carcinoma, Bladder Urothelial Carcinoma, Bladder Urothelial Carcinoma, Bladder Urothelial Carcinoma, Head And Neck Squamous Cell Carcinoma , Head And Neck Squamous Cell Carcinoma , Liver Hepatocellular Carcinoma, Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma, Kidney Renal Papillary Cell Carcinoma, Bladder Urothelial Carcinoma, Brain Lower Grade Glioma, Esophageal Carcinoma, Esophageal Carcinoma, Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma, Brain Lower Grade Glioma, Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma, Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma, Bladder Urothelial Carcinoma, Bladder Urothelial Carcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGFR3-TACC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-RERE | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-REOR | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-REGO | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-REGR | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-REAQ | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-ORRE | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-OROR | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-ORGO | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-GORE | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-GOOR | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-GOGO | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-GOGR | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-GRRE | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-GROR | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-GRGO | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-GRGR | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-AQRE | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-AQOR | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-AQGO | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-AQGR | 20 (40 μL) | 200 μL |
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| FGFR3-TACC3-20-AQAQ | 20 (40 μL) | 200 μL |
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FGFR3 Gene Summary
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017]
Gene Name: Fibroblast Growth Factor Receptor 3
Chromosome: CHR4: 1795038 -1810599
Locus: 4p16.3
TACC3 Gene Summary
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
Gene Name: Transforming Acidic Coiled-coil Containing Protein 3
Chromosome: CHR4: 1723265 -1746897
Locus: 4p16.3
Gene Diseases
The FGFR3 TACC3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Glioblastoma Multiforme |
| Glioblastoma Multiforme |
| Glioblastoma Multiforme |
| Glioblastoma Multiforme |
| Lung Squamous Cell Carcinoma |
| Lung Squamous Cell Carcinoma |
| Lung Adenocarcinoma |
| Lung Squamous Cell Carcinoma |
| Lung Squamous Cell Carcinoma |
| Lung Squamous Cell Carcinoma |
| Lung Squamous Cell Carcinoma |
| Kidney Renal Papillary Cell Carcinoma |
| Bladder Urothelial Carcinoma |
| Bladder Urothelial Carcinoma |
| Bladder Urothelial Carcinoma |
| Bladder Urothelial Carcinoma |
| Bladder Urothelial Carcinoma |
| Bladder Urothelial Carcinoma |
| Head And Neck Squamous Cell Carcinoma |
| Head And Neck Squamous Cell Carcinoma |
| Liver Hepatocellular Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
| Kidney Renal Papillary Cell Carcinoma |
| Bladder Urothelial Carcinoma |
| Brain Lower Grade Glioma |
| Esophageal Carcinoma |
| Esophageal Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
| Brain Lower Grade Glioma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
| Bladder Urothelial Carcinoma |
| Bladder Urothelial Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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