FGFR3-FBXO28 Fusion FISH Probe
The FGFR3-FBXO28 Fusion FISH Probe is used to confirm a fusion of the FGFR3 and FBXO28 genes. The fusion of the FGFR3 and FBXO28 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FGFR3-FBXO28-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-RERE | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-REOR | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-REGO | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-REGR | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-OROR | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-GORE | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-GROR | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| FGFR3-FBXO28-20-AQAQ | 20 (40 μL) | 200 μL |
|
FGFR3 Gene Summary
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017]
Gene Name: Fibroblast Growth Factor Receptor 3
Chromosome: CHR4: 1795038 -1810599
Locus: 4p16.3
FBXO28 Gene Summary
Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Name: F-box Protein 28
Chromosome: CHR1: 224301790 -224349749
Locus: 1q42.11
Gene Diseases
The FGFR3 FBXO28 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|