FGFR3-AES Fusion FISH Probe
The FGFR3-AES Fusion FISH Probe is used to confirm a fusion of the FGFR3 and AES genes. The fusion of the FGFR3 and AES genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGFR3-AES-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-RERE | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-REOR | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-REGO | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-REGR | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-REAQ | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-ORRE | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-OROR | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-ORGO | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-GORE | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-GOOR | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-GOGO | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-GOGR | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-GRRE | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-GROR | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-GRGO | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-GRGR | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-AQRE | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-AQOR | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-AQGO | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-AQGR | 20 (40 μL) | 200 μL |
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| FGFR3-AES-20-AQAQ | 20 (40 μL) | 200 μL |
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AES Gene Summary
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Amino-terminal Enhancer Of Split
Chromosome: CHR19: 3052907 -3062964
Locus: 19p13.3
FGFR3 Gene Summary
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017]
Gene Name: Fibroblast Growth Factor Receptor 3
Chromosome: CHR4: 1795038 -1810599
Locus: 4p16.3
Gene Diseases
The FGFR3 AES Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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