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FGFR3-AES Fusion FISH Probe

The FGFR3-AES Fusion FISH Probe is used to confirm a fusion of the FGFR3 and AES genes. The fusion of the FGFR3 and AES genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
FGFR3-AES-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
FGFR3-AES-20-RERE 20 (40 μL) 200 μL
FGFR3-AES-20-REOR 20 (40 μL) 200 μL
FGFR3-AES-20-REGO 20 (40 μL) 200 μL
FGFR3-AES-20-REGR 20 (40 μL) 200 μL
FGFR3-AES-20-REAQ 20 (40 μL) 200 μL
FGFR3-AES-20-ORRE 20 (40 μL) 200 μL
FGFR3-AES-20-OROR 20 (40 μL) 200 μL
FGFR3-AES-20-ORGO 20 (40 μL) 200 μL
FGFR3-AES-20-ORAQ 20 (40 μL) 200 μL
FGFR3-AES-20-GORE 20 (40 μL) 200 μL
FGFR3-AES-20-GOOR 20 (40 μL) 200 μL
FGFR3-AES-20-GOGO 20 (40 μL) 200 μL
FGFR3-AES-20-GOGR 20 (40 μL) 200 μL
FGFR3-AES-20-GOAQ 20 (40 μL) 200 μL
FGFR3-AES-20-GRRE 20 (40 μL) 200 μL
FGFR3-AES-20-GROR 20 (40 μL) 200 μL
FGFR3-AES-20-GRGO 20 (40 μL) 200 μL
FGFR3-AES-20-GRGR 20 (40 μL) 200 μL
FGFR3-AES-20-GRAQ 20 (40 μL) 200 μL
FGFR3-AES-20-AQRE 20 (40 μL) 200 μL
FGFR3-AES-20-AQOR 20 (40 μL) 200 μL
FGFR3-AES-20-AQGO 20 (40 μL) 200 μL
FGFR3-AES-20-AQGR 20 (40 μL) 200 μL
FGFR3-AES-20-AQAQ 20 (40 μL) 200 μL

AES Gene Summary

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Name: Amino-terminal Enhancer Of Split

Chromosome: CHR19: 3052907 -3062964

Locus: 19p13.3

FGFR3 Gene Summary

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017]

Gene Name: Fibroblast Growth Factor Receptor 3

Chromosome: CHR4: 1795038 -1810599

Locus: 4p16.3

Gene Diseases

The FGFR3 AES Fusion has been associated with the following diseases:

Disease Name
Prostate Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.