FGFR2-USP10 Fusion FISH Probe
The FGFR2-USP10 Fusion FISH Probe is used to confirm a fusion of the FGFR2 and USP10 genes. The fusion of the FGFR2 and USP10 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGFR2-USP10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-RERE | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-REOR | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-REGO | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-REGR | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-REAQ | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-ORRE | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-OROR | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-ORGO | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-GORE | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-GOOR | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-GOGO | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-GOGR | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-GRRE | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-GROR | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-GRGO | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-GRGR | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-AQRE | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-AQOR | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-AQGO | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-AQGR | 20 (40 μL) | 200 μL |
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| FGFR2-USP10-20-AQAQ | 20 (40 μL) | 200 μL |
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FGFR2 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Gene Name: Fibroblast Growth Factor Receptor 2
Chromosome: CHR10: 123237843 -123357972
Locus: 10q26.13
USP10 Gene Summary
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Name: Ubiquitin Specific Peptidase 10
Chromosome: CHR16: 84733554 -84813527
Locus: 16q24.1
Gene Diseases
The FGFR2 USP10 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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