FGFR2-TACC2 Fusion FISH Probe
The FGFR2-TACC2 Fusion FISH Probe is used to confirm a fusion of the FGFR2 and TACC2 genes. The fusion of the FGFR2 and TACC2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGFR2-TACC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-RERE | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-REOR | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-REGO | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-REGR | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-REAQ | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-ORRE | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-OROR | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-ORGO | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-GORE | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-GOOR | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-GOGO | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-GOGR | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-GRRE | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-GROR | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-GRGO | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-GRGR | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-AQRE | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-AQOR | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-AQGO | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-AQGR | 20 (40 μL) | 200 μL |
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| FGFR2-TACC2-20-AQAQ | 20 (40 μL) | 200 μL |
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FGFR2 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Gene Name: Fibroblast Growth Factor Receptor 2
Chromosome: CHR10: 123237843 -123357972
Locus: 10q26.13
TACC2 Gene Summary
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Transforming Acidic Coiled-coil Containing Protein 2
Chromosome: CHR10: 123748688 -124014057
Locus: 10q26.13
Gene Diseases
The FGFR2 TACC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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