FGFR2-OFD1 Fusion FISH Probe
The FGFR2-OFD1 Fusion FISH Probe is used to confirm a fusion of the FGFR2 and OFD1 genes. The fusion of the FGFR2 and OFD1 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGFR2-OFD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-RERE | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-REOR | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-REGO | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-REGR | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-REAQ | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-ORRE | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-OROR | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-ORGO | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-GORE | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-GOOR | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-GOGO | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-GOGR | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-GRRE | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-GROR | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-GRGO | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-GRGR | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-AQRE | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-AQOR | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-AQGO | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-AQGR | 20 (40 μL) | 200 μL |
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| FGFR2-OFD1-20-AQAQ | 20 (40 μL) | 200 μL |
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FGFR2 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Gene Name: Fibroblast Growth Factor Receptor 2
Chromosome: CHR10: 123237843 -123357972
Locus: 10q26.13
OFD1 Gene Summary
This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, however, unlike the human gene it is not subject to X inactivation. Mutations in this gene are associated with oral-facial-digital syndrome type I and Simpson-Golabi-Behmel syndrome type 2. Many pseudogenes have been identified; a single pseudogene is found on chromosome 5 while as many as fifteen have been found on the Y chromosome. [provided by RefSeq, Aug 2016]
Gene Name: OFD1, Centriole And Centriolar Satellite Protein
Chromosome: CHRX: 13752831 -13787480
Locus: Xp22.2
Gene Diseases
The FGFR2 OFD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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