FGFR2-CCDC6 Fusion FISH Probe
The FGFR2-CCDC6 Fusion FISH Probe is used to confirm a fusion of the FGFR2 and CCDC6 genes. The fusion of the FGFR2 and CCDC6 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGFR2-CCDC6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-RERE | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-REOR | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-REGO | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-REGR | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-REAQ | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-ORRE | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-OROR | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-ORGO | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-GORE | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-GOOR | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-GOGO | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-GOGR | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-GRRE | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-GROR | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-GRGO | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-GRGR | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-AQRE | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-AQOR | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-AQGO | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-AQGR | 20 (40 μL) | 200 μL |
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| FGFR2-CCDC6-20-AQAQ | 20 (40 μL) | 200 μL |
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FGFR2 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Gene Name: Fibroblast Growth Factor Receptor 2
Chromosome: CHR10: 123237843 -123357972
Locus: 10q26.13
CCDC6 Gene Summary
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]
Gene Name: Coiled-coil Domain Containing 6
Chromosome: CHR10: 61548505 -61666414
Locus: 10q21.2
Gene Diseases
The FGFR2 CCDC6 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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