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FGFR2-BICC1 Fusion FISH Probe

The FGFR2-BICC1 Fusion FISH Probe is used to confirm a fusion of the FGFR2 and BICC1 genes. The fusion of the FGFR2 and BICC1 genes has been associated with Liver Hepatocellular Carcinoma, Cholangiocarcinoma, and Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
FGFR2-BICC1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
FGFR2-BICC1-20-RERE 20 (40 μL) 200 μL
FGFR2-BICC1-20-REOR 20 (40 μL) 200 μL
FGFR2-BICC1-20-REGO 20 (40 μL) 200 μL
FGFR2-BICC1-20-REGR 20 (40 μL) 200 μL
FGFR2-BICC1-20-REAQ 20 (40 μL) 200 μL
FGFR2-BICC1-20-ORRE 20 (40 μL) 200 μL
FGFR2-BICC1-20-OROR 20 (40 μL) 200 μL
FGFR2-BICC1-20-ORGO 20 (40 μL) 200 μL
FGFR2-BICC1-20-ORAQ 20 (40 μL) 200 μL
FGFR2-BICC1-20-GORE 20 (40 μL) 200 μL
FGFR2-BICC1-20-GOOR 20 (40 μL) 200 μL
FGFR2-BICC1-20-GOGO 20 (40 μL) 200 μL
FGFR2-BICC1-20-GOGR 20 (40 μL) 200 μL
FGFR2-BICC1-20-GOAQ 20 (40 μL) 200 μL
FGFR2-BICC1-20-GRRE 20 (40 μL) 200 μL
FGFR2-BICC1-20-GROR 20 (40 μL) 200 μL
FGFR2-BICC1-20-GRGO 20 (40 μL) 200 μL
FGFR2-BICC1-20-GRGR 20 (40 μL) 200 μL
FGFR2-BICC1-20-GRAQ 20 (40 μL) 200 μL
FGFR2-BICC1-20-AQRE 20 (40 μL) 200 μL
FGFR2-BICC1-20-AQOR 20 (40 μL) 200 μL
FGFR2-BICC1-20-AQGO 20 (40 μL) 200 μL
FGFR2-BICC1-20-AQGR 20 (40 μL) 200 μL
FGFR2-BICC1-20-AQAQ 20 (40 μL) 200 μL

FGFR2 Gene Summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Gene Name: Fibroblast Growth Factor Receptor 2

Chromosome: CHR10: 123237843 -123357972

Locus: 10q26.13

BICC1 Gene Summary

This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]

Gene Name: BicC Family RNA Binding Protein 1

Chromosome: CHR10: 60272903 -60588845

Locus: 10q21.1

Gene Diseases

The FGFR2 BICC1 Fusion has been associated with the following diseases:

Disease Name
Liver Hepatocellular Carcinoma
Cholangiocarcinoma
Cholangiocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.