FGFR1OP-MCM9 Fusion FISH Probe
The FGFR1OP-MCM9 Fusion FISH Probe is used to confirm a fusion of the FGFR1OP and MCM9 genes. The fusion of the FGFR1OP and MCM9 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGFR1OP-MCM9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-RERE | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-REOR | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-REGO | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-REGR | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-REAQ | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-ORRE | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-OROR | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-ORGO | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-GORE | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-GOOR | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-GOGO | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-GOGR | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-GRRE | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-GROR | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-GRGO | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-GRGR | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-AQRE | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-AQOR | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-AQGO | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-AQGR | 20 (40 μL) | 200 μL |
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| FGFR1OP-MCM9-20-AQAQ | 20 (40 μL) | 200 μL |
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FGFR1OP Gene Summary
This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
Gene Name: FGFR1 Oncogene Partner
Chromosome: CHR6: 167412815 -167454066
Locus: 6q27
MCM9 Gene Summary
The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]
Gene Name: Minichromosome Maintenance 9 Homologous Recombination Repair Factor
Chromosome: CHR6: 119134611 -119252903
Locus: 6q22.31
Gene Diseases
The FGFR1OP MCM9 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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