FGFR1OP-ABCC4 Fusion FISH Probe
The FGFR1OP-ABCC4 Fusion FISH Probe is used to confirm a fusion of the FGFR1OP and ABCC4 genes. The fusion of the FGFR1OP and ABCC4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGFR1OP-ABCC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-RERE | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-REOR | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-REGO | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-REGR | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-REAQ | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-ORRE | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-OROR | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-ORGO | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-GORE | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-GOOR | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-GOGO | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-GOGR | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-GRRE | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-GROR | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-GRGO | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-GRGR | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-AQRE | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-AQOR | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-AQGO | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-AQGR | 20 (40 μL) | 200 μL |
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| FGFR1OP-ABCC4-20-AQAQ | 20 (40 μL) | 200 μL |
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ABCC4 Gene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Name: ATP Binding Cassette Subfamily C Member 4
Chromosome: CHR13: 95672082 -95953687
Locus: 13q32.1
FGFR1OP Gene Summary
This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
Gene Name: FGFR1 Oncogene Partner
Chromosome: CHR6: 167412815 -167454066
Locus: 6q27
Gene Diseases
The FGFR1OP ABCC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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