FGFR1-ADAM18 Fusion FISH Probe
The FGFR1-ADAM18 Fusion FISH Probe is used to confirm a fusion of the FGFR1 and ADAM18 genes. The fusion of the FGFR1 and ADAM18 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGFR1-ADAM18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-RERE | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-REOR | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-REGO | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-REGR | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-REAQ | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-ORRE | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-OROR | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-ORGO | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-GORE | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-GOOR | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-GOGO | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-GOGR | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-GRRE | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-GROR | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-GRGO | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-GRGR | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-AQRE | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-AQOR | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-AQGO | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-AQGR | 20 (40 μL) | 200 μL |
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| FGFR1-ADAM18-20-AQAQ | 20 (40 μL) | 200 μL |
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FGFR1 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Fibroblast Growth Factor Receptor 1
Chromosome: CHR8: 38268655 -38326352
Locus: 8p11.23
ADAM18 Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: ADAM Metallopeptidase Domain 18
Chromosome: CHR8: 39442086 -39587583
Locus: 8p11.22
Gene Diseases
The FGFR1 ADAM18 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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