FGF13-NLRP3 Fusion FISH Probe
The FGF13-NLRP3 Fusion FISH Probe is used to confirm a fusion of the FGF13 and NLRP3 genes. The fusion of the FGF13 and NLRP3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FGF13-NLRP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| FGF13-NLRP3-20-AQAQ | 20 (40 μL) | 200 μL |
|
FGF13 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]
Gene Name: Fibroblast Growth Factor 13
Chromosome: CHRX: 137713733 -138287185
Locus: Xq26.3-q27.1
NLRP3 Gene Summary
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
Gene Name: NLR Family Pyrin Domain Containing 3
Chromosome: CHR1: 247579457 -247612406
Locus: 1q44
Gene Diseases
The FGF13 NLRP3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|