FGF12-SYN3 Fusion FISH Probe
The FGF12-SYN3 Fusion FISH Probe is used to confirm a fusion of the FGF12 and SYN3 genes. The fusion of the FGF12 and SYN3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGF12-SYN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-RERE | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-REOR | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-REGO | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-REGR | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-REAQ | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-ORRE | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-OROR | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-ORGO | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-GORE | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-GOOR | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-GOGO | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-GOGR | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-GRRE | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-GROR | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-GRGO | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-GRGR | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-AQRE | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-AQOR | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-AQGO | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-AQGR | 20 (40 μL) | 200 μL |
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| FGF12-SYN3-20-AQAQ | 20 (40 μL) | 200 μL |
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FGF12 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Fibroblast Growth Factor 12
Chromosome: CHR3: 191857181 -192445388
Locus: 3q28-q29
SYN3 Gene Summary
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in multiple splice variants that encode different isoforms. [provided by RefSeq, Oct 2008]
Gene Name: Synapsin III
Chromosome: CHR22: 32908539 -33454377
Locus: 22q12.3
Gene Diseases
The FGF12 SYN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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