FGF12-LAMP3 Fusion FISH Probe
The FGF12-LAMP3 Fusion FISH Probe is used to confirm a fusion of the FGF12 and LAMP3 genes. The fusion of the FGF12 and LAMP3 genes has been associated with Brain Lower Grade Glioma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGF12-LAMP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-RERE | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-REOR | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-REGO | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-REGR | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-REAQ | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-ORRE | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-OROR | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-ORGO | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-GORE | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-GOOR | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-GOGO | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-GOGR | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-GRRE | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-GROR | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-GRGO | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-GRGR | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-AQRE | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-AQOR | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-AQGO | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-AQGR | 20 (40 μL) | 200 μL |
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| FGF12-LAMP3-20-AQAQ | 20 (40 μL) | 200 μL |
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FGF12 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Fibroblast Growth Factor 12
Chromosome: CHR3: 191857181 -192445388
Locus: 3q28-q29
LAMP3 Gene Summary
Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]
Gene Name: Lysosomal Associated Membrane Protein 3
Chromosome: CHR3: 182840002 -182880667
Locus: 3q27.1
Gene Diseases
The FGF12 LAMP3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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