FGD4-VPS13D Fusion FISH Probe
The FGD4-VPS13D Fusion FISH Probe is used to confirm a fusion of the FGD4 and VPS13D genes. The fusion of the FGD4 and VPS13D genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGD4-VPS13D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-RERE | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-REOR | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-REGO | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-REGR | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-REAQ | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-ORRE | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-OROR | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-ORGO | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-GORE | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-GOOR | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-GOGO | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-GOGR | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-GRRE | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-GROR | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-GRGO | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-GRGR | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-AQRE | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-AQOR | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-AQGO | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-AQGR | 20 (40 μL) | 200 μL |
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| FGD4-VPS13D-20-AQAQ | 20 (40 μL) | 200 μL |
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VPS13D Gene Summary
This gene encodes a protein belonging to the vacuolar-protein-sorting-13 gene family. In yeast, vacuolar-protein-sorting-13 proteins are involved in trafficking of membrane proteins between the trans-Golgi network and the prevacuolar compartment. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Vacuolar Protein Sorting 13 Homolog D
Chromosome: CHR1: 12290112 -12572098
Locus: 1p36.22-p36.21
FGD4 Gene Summary
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Gene Name: FYVE, RhoGEF And PH Domain Containing 4
Chromosome: CHR12: 32655040 -32798984
Locus: 12p11.21
Gene Diseases
The FGD4 VPS13D Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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