FGD4-MRPS35 Fusion FISH Probe
The FGD4-MRPS35 Fusion FISH Probe is used to confirm a fusion of the FGD4 and MRPS35 genes. The fusion of the FGD4 and MRPS35 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGD4-MRPS35-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-RERE | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-REOR | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-REGO | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-REGR | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-REAQ | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-ORRE | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-OROR | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-ORGO | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-GORE | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-GOOR | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-GOGO | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-GOGR | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-GRRE | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-GROR | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-GRGO | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-GRGR | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-AQRE | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-AQOR | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-AQGO | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-AQGR | 20 (40 μL) | 200 μL |
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| FGD4-MRPS35-20-AQAQ | 20 (40 μL) | 200 μL |
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MRPS35 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
Gene Name: Mitochondrial Ribosomal Protein S35
Chromosome: CHR12: 27863705 -27909237
Locus: 12p11.22
FGD4 Gene Summary
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Gene Name: FYVE, RhoGEF And PH Domain Containing 4
Chromosome: CHR12: 32655040 -32798984
Locus: 12p11.21
Gene Diseases
The FGD4 MRPS35 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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