FGD4-CD4 Fusion FISH Probe
The FGD4-CD4 Fusion FISH Probe is used to confirm a fusion of the FGD4 and CD4 genes. The fusion of the FGD4 and CD4 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGD4-CD4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-RERE | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-REOR | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-REGO | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-REGR | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-REAQ | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-ORRE | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-OROR | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-ORGO | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-GORE | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-GOOR | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-GOGO | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-GOGR | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-GRRE | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-GROR | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-GRGO | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-GRGR | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-AQRE | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-AQOR | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-AQGO | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-AQGR | 20 (40 μL) | 200 μL |
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| FGD4-CD4-20-AQAQ | 20 (40 μL) | 200 μL |
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CD4 Gene Summary
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
Gene Name: CD4 Molecule
Chromosome: CHR12: 6898637 -6929976
Locus: 12p13.31
FGD4 Gene Summary
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Gene Name: FYVE, RhoGEF And PH Domain Containing 4
Chromosome: CHR12: 32655040 -32798984
Locus: 12p11.21
Gene Diseases
The FGD4 CD4 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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