FGB-STAT6 Fusion FISH Probe
The FGB-STAT6 Fusion FISH Probe is used to confirm a fusion of the FGB and STAT6 genes. The fusion of the FGB and STAT6 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FGB-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| FGB-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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FGB Gene Summary
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Gene Name: Fibrinogen Beta Chain
Chromosome: CHR4: 155484131 -155493915
Locus: 4q31.3
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The FGB STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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