FER-FBXL17 Fusion FISH Probe
The FER-FBXL17 Fusion FISH Probe is used to confirm a fusion of the FER and FBXL17 genes. The fusion of the FER and FBXL17 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FER-FBXL17-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-RERE | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-REOR | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-REGO | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-REGR | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-REAQ | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-ORRE | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-OROR | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-ORGO | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-ORAQ | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-GORE | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-GOOR | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-GOGO | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-GOGR | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-GOAQ | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-GRRE | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-GROR | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-GRGO | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-GRGR | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-GRAQ | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-AQRE | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-AQOR | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-AQGO | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-AQGR | 20 (40 μL) | 200 μL |
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| FER-FBXL17-20-AQAQ | 20 (40 μL) | 200 μL |
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FER Gene Summary
The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]
Gene Name: FER Tyrosine Kinase
Chromosome: CHR5: 108083522 -108523373
Locus: 5q21.3
FBXL17 Gene Summary
Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Name: F-box And Leucine Rich Repeat Protein 17
Chromosome: CHR5: 107194733 -107717799
Locus: 5q21.3
Gene Diseases
The FER FBXL17 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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