FEN1-GDPD4 Fusion FISH Probe
The FEN1-GDPD4 Fusion FISH Probe is used to confirm a fusion of the FEN1 and GDPD4 genes. The fusion of the FEN1 and GDPD4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FEN1-GDPD4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-RERE | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-REOR | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-REGO | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-REGR | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-REAQ | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-ORRE | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-OROR | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-ORGO | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-ORAQ | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-GORE | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-GOOR | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-GOGO | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-GOGR | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-GOAQ | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-GRRE | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-GROR | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-GRGO | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-GRGR | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-GRAQ | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-AQRE | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-AQOR | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-AQGO | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-AQGR | 20 (40 μL) | 200 μL |
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| FEN1-GDPD4-20-AQAQ | 20 (40 μL) | 200 μL |
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FEN1 Gene Summary
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
Gene Name: Flap Structure-specific Endonuclease 1
Chromosome: CHR11: 61560108 -61564714
Locus: 11q12.2
GDPD4 Gene Summary
The Glycerophosphodiester Phosphodiesterase Domain Containing 4 (GDPD4) gene is located on chr11 :76927602-76998463 at 11q13.5.
Gene Name: Glycerophosphodiester Phosphodiesterase Domain Containing 4
Chromosome: CHR11: 76927602 -76998463
Locus: 11q13.5
Gene Diseases
The FEN1 GDPD4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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