FDXACB1-CRYAB Fusion FISH Probe
The FDXACB1-CRYAB Fusion FISH Probe is used to confirm a fusion of the FDXACB1 and CRYAB genes. The fusion of the FDXACB1 and CRYAB genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FDXACB1-CRYAB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-RERE | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-REOR | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-REGO | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-REGR | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-REAQ | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-ORRE | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-OROR | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-ORGO | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-ORAQ | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-GORE | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-GOOR | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-GOGO | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-GOGR | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-GOAQ | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-GRRE | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-GROR | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-GRGO | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-GRGR | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-GRAQ | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-AQRE | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-AQOR | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-AQGO | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-AQGR | 20 (40 μL) | 200 μL |
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| FDXACB1-CRYAB-20-AQAQ | 20 (40 μL) | 200 μL |
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CRYAB Gene Summary
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: Crystallin Alpha B
Chromosome: CHR11: 111779349 -111782473
Locus: 11q23.1
FDXACB1 Gene Summary
This gene encodes a protein which contains a ferredoxin-fold anticodon-binding domain which is contained in a subset of phenylalanyl tRNA synthetases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Ferredoxin-fold Anticodon Binding Domain Containing 1
Chromosome: CHR11: 111744779 -111750181
Locus: 11q23.1
Gene Diseases
The FDXACB1 CRYAB Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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