FDFT1-NEIL2 Fusion FISH Probe
The FDFT1-NEIL2 Fusion FISH Probe is used to confirm a fusion of the FDFT1 and NEIL2 genes. The fusion of the FDFT1 and NEIL2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FDFT1-NEIL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| FDFT1-NEIL2-20-AQAQ | 20 (40 μL) | 200 μL |
|
FDFT1 Gene Summary
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
Gene Name: Farnesyl-diphosphate Farnesyltransferase 1
Chromosome: CHR8: 11660189 -11696818
Locus: 8p23.1
NEIL2 Gene Summary
This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]
Gene Name: Nei Like DNA Glycosylase 2
Chromosome: CHR8: 11627171 -11644854
Locus: 8p23.1
Gene Diseases
The FDFT1 NEIL2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|